Preheat the Oven: Preheat your oven to 350°F (175°C).
Prepare the Sliders: Slice the slider rolls in half and place the bottom halves in a baking dish. Layer each roll with a slice of ham and a slice of cheese.
Make the Butter Mixture: In a small bowl, mix together the melted butter, Dijon mustard, Worcestershire sauce, garlic powder, onion powder, poppy seeds, salt, and pepper.
Assemble and Brush: Place the top halves of the rolls on top of the cheese. Brush the butter mixture generously over the tops of the sliders.
Bake: Cover the dish with aluminum foil and bake for 15 minutes. Remove the foil and bake for an additional 10-15 minutes, or until the cheese is melted and the tops are golden brown.
Serve: Remove from the oven, let cool slightly, and serve warm. Enjoy these sliders as the perfect fun finger foods for any occasion!